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Autor: Fernández, V. ; Videla, L. ; Videla, L.
Título: ESTRATEGIAS EXPERIMENTALES DE PREACONDICIONAMIENTO HEPÁTICO
EXPERIMENTAL LIVER PRECONDITIONING STRATEGIES
ISSN: 1690-8414
Fecha: 2014
Páginas/Colación: pp. 17-22
En:/ Gaceta de Ciencias Veterinarias Vol 19 Nro.1 Julio 2014
Información de existenciaInformación de existencia
Categoría Temática: Palabras: VET01 VET01
Descriptor Temático: Palabras: HÍGADO HÍGADO, Palabras: HORMONA TIROIDEA HORMONA TIROIDEA, Palabras: PREACONDICIONAMIENTO PREACONDICIONAMIENTO, Palabras: RATA RATA
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RESUMEN
El preacondicionamiento hepático (PC) aumenta la tolerancia a estímulos injuriantes como la isquemiareperfusión (IR), el cual es inducido por estrategias previas que gatillan cambios moleculares y funcionales beneficiosos, lo cual es importante en cirugías hepáticas en el hombre. Ellas incluyen maniobras quirúrgicas y farmacológicas experimentales que tienen limitaciones para su aplicación clínica. Recientemente, se ha estudiado el PC por hormona tiroídea (T3) que suprime el daño hepático inducido por IR. Los mecanismos subyacentes en el PC por T3 involucran la inducción de proteínas con acción protectora y asociadas a la proliferación celular, vía la activación redox de los factores transcripcionales, NF-KB, AP-1, STAT3 y Nrf2, con el apoyo energético mediado por la activación de la proteína quinasa activada por AMP (AMPK). El PC por hormonas tiroídeas no solo se observa en el hígado, sino que también en el corazón, riñón y cerebro frente al daño por IR o por otros estímulos deletéreos.
Palabras Claves del Autor: Rata, hígado, preacondicionamiento, hormona tiroidea.

ABSTRACT
Liver preconditioning (PC) increases tolerance to injuring stimuli such as ischemia-reperfusion (IR), which is induced by previous maneuvers triggering beneficial molecular and functional changes that are important in human liver surgery. These include experimental surgical and pharmacological strategies that have limitations for their clinical application. Recently, thyroid hormone (T3) PC has been studied, which suppresses IR-induced liver injury. The underlying mechanisms of T3-induced liver PC involve the induction of protective proteins and those associated with cell proliferation, through the redox activation of transcription factors NFKB, AP-1, STAT3, and Nrf2, with energy support being given by the activation of AMP-activated protein kinase (AMPK). Thyroid hormone-induced PC is not restricted to the liver, but protective effects are also observed in heart, kidney, and brain against IR-induced injury or other types of damaging stimuli.
Key words: Rat, liver, preconditioning, thyroid hormone.

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